Health
Myasthenia Gravis
MYASTHENIA GRAVIS
Myasthenia gravis. The way your nerves and muscles communicate is impacted by myasthenia gravis. Muscle weakness results, which gets worse with activities and throughout the day. Double vision and/or drooping eyelids are frequently the initial symptoms. You can have trouble speaking, swallowing, standing, and lifting things. The symptoms of this chronic condition can be lessened with medication and surgery.
MYASTHENIA GRAVIS
In myasthenia gravis (MG), the body’s immune system unintentionally targets the neuromuscular junction, the point where muscles and nerves communicate, resulting in fluctuating weakness of skeletal muscles, mainly those controlling chewing, swallowing, speaking, eye and facial movements, and limb movements. MG is a chronic autoimmune condition disorder.
Types
The etiology of autoimmune myasthenia is unknown; however, it is most likely due to the creation of specific antibodies (immune system proteins). This is the most prevalent kind.
A fetus with myasthenia gravis receives specific antibodies from its birth mother, which causes neonatal myasthenia. A baby may be born with a faint cry or sucking reflex. These transient symptoms typically disappear after three months.
Congenital myopathy
Ocular: Your eyelids’ and eyes’ moving muscles deteriorate. You might have trouble keeping your eyes open or your eyelids may droop. Double vision happens to some people. The initial symptom of myasthenia is frequently eye weakness. For about 50% of those with ocular myasthenia gravis, the condition may progress to the generalized form.
Eye muscles, as well as those in your face, neck, arms, legs, and throat, are all affected by generalized muscle weakness. Speaking or swallowing, raising your arms above your head, getting out of a chair, walking long distances, and climbing stairs may become challenging for you.
Symptoms
Myasthenia gravis symptoms can include weakness in the arms, hands, fingers, legs, and neck muscles.
Fatigue.
eyelid drooping (ptosis).
double or blurry vision.
restricted expressions on the face.
difficulty swallowing, chewing, or speaking.
Walking is difficult.
Myasthenia gravis’s early symptoms appear suddenly. Generally speaking, being active weakens your muscles. When you rest, your muscles become stronger again. Muscle weakness frequently varies in intensity from day to day. At the beginning of the day, most people feel their strongest, and at the end of the day, their weakest.
Causes
When your body’s immune system unintentionally targets itself, you can develop myasthenia gravis (autoimmune type). Why this occurs is unknown to researchers. According to studies, some immune system cells in the thymus gland may struggle to distinguish between substances that are healthy and those that pose a harm to your body, such as bacteria or viruses. Congenital myasthenia is brought on by a genetic mutation. Neonatal myasthenia is brought on by antibodies that are transferred from the birth mother to the fetus during pregnancy.
Treatment
For myasthenia gravis, there is no known treatment. However, there is a useful medication that might help you control your symptoms. Possible treatments include:
Pharmaceuticals: Some drugs can lessen your symptoms.
Monoclonal antibodies: You will be given biologically modified proteins either intravenously (IV) or subcutaneously (SQ). When the immune system is overactive, these proteins dampen it.
Plasma exchange, also known as plasmapheresis, is a procedure in which a machine-connected IV extracts dangerous antibodies from your blood plasma and substitutes them with donor plasma or a plasma solution.
Donor antibodies will be infused into your veins over the course of two to five days using IV or SQ immunoglobulin (IVIG or SCIG). Both myasthenia crises and generalized myasthenia gravis can be treated with IVIG or SCIG.
Surgery to remove the thymus gland is called a thymectomy.
Summary
Living with a chronic condition like myasthenia gravis is difficult. You may feel too weak or exhausted to engage in physical activity when you want to. Over time, this may have a negative impact on your physical and mental well-being. With treatment, the majority of persons with this ailment enjoy active, complete lives despite the lack of a cure. It is quite uncommon for myasthenia gravis to cause severe disability. To help you feel better, your healthcare professional might offer symptom management advice.
PERIPHERAL NEUROPATHY
Peripheral neuropathy. The general term for nerve disorders that impact a particular segment of your nervous system is peripheral neuropathy. Since it can be caused by a variety of disorders, a wide range of symptoms may also be present. The way and cause of peripheral neuropathy can also determine which bodily regions are affected.
PERIPHERAL NEUROPATHY
Damage to the peripheral nerves that link the brain and spinal cord to the rest of the body causes this disorder, which manifests as a range of symptoms include tingling, pain, weakness, and numbness. Along with affecting digestion and urination, it can also affect other parts of the body, such as the hands and feet.
Types
Demyelinating neuropathy: This condition occurs when the axon’s myelin sheath breaks down or fails to develop properly. This has an impact on how signals move through the neuron.
Axonal degeneration: This results in the axon’s degradation and eventual death. The effect is worse the longer the neuron. Your legs and feet, which are located furthest from your spinal cord and depend on connections made by longer axons, are therefore frequently affected by axonal degeneration disorders. The most prevalent pattern of peripheral neuropathy is axonal degeneration.
Symptoms
It can present with a variety of symptoms. A single nerve, an interconnected network of related nerves, or numerous nerves spread throughout your body may be impacted by this illness. Multiple signal types may be implicated, and the symptoms also depend on the sort of nerve signals that are impacted.
The sorts of symptoms (more on these are provided below) are:
Motor.
both pain and sensory.
Autonomic.
Causes
Diabetes type 2. Type 2 diabetes that is left untreated is the most frequent cause of peripheral neuropathy. Excessive blood sugar levels over an extended period of time can harm peripheral nerves. People who have type 2 diabetes may therefore experience a loss of sensation in their lower legs and feet.
addiction to alcohol. Nerve injury can result from excessive alcohol consumption, particularly over extended periods of time. In addition to contributing to vitamin deficiencies that produce peripheral neuropathy, alcohol use disorder is a common cause of peripheral neuropathy.
nutritional and vitamin deficits. When a person is deficient in certain vitamins, nerve injury may result.
Treatment
Medications. Peripheral nervous system issues can be treated with a variety of drugs. These can take many different forms, such as oral pills, injections, skin-sticking patches, slow-release drugs, and more.
Surgery. Reconnecting severed nerves and relieving pain from imprisoned nerves can be accomplished by surgery. In order to prevent damaged or defective nerves from sending signals to the brain and vice versa, it can also cut or delete them.
physical treatment. This might lessen pain symptoms or aid in your recovery from illnesses or injuries. Along with enhancing balance and reducing the risk of falls, it can also assist you in adjusting to changes in your neurological system.
Summary
Peripheral neuropathy may be curable, transient, or both for certain individuals. For others, it’s incurable and permanent. Many of the symptoms or manifestations of peripheral neuropathy can now be treated because of advancements in medical research and technology. Many people can live longer and with fewer limitations or effects from the associated diseases and symptoms if they manage this condition.
PENILE CANCER
Penile cancer. When your penis’s healthy cells alter and proliferate uncontrollably, penile cancer results. The rod-shaped reproductive organ that enables urination and sexual activity is your penis. It consists of the glans, a rod-like region (shaft) that runs from your low abdomen to the tip of your penis. The foreskin is a layer of skin that covers the head if you are not circumcised. Your penis’ head is visible if you have had circumcision.
PENILE CANCER
Cancer can develop anywhere in the penis, but if you are not circumcised, it usually begins on the head or foreskin. Penile cancer, a relatively uncommon cancer of the penis, is frequently a squamous cell carcinoma, originating from the skin cells. Uncircumcision, HPV infection, smoking, and poor hygiene are risk factors. Successful treatment, which may include chemotherapy, radiation, or surgery, depends on early detection.
Types
SCC stands for squamous cell cancer. The epithelium, the outermost layer of your skin, is where this cancer develops. 95% of all penile malignancies are of this type.
Melanoma. Melanocytes, the cells that regulate how dark or light your skin is, are where this type of cancer starts. A more aggressive type of cancer is melanoma.
BCC, or basal cell cancer. The lowermost layer of your epithelium is where the cancer starts. BCC is a type of penile cancer that grows slowly.
Adenocarcinoma. Your glandular cells, which produce perspiration, mucus, and other bodily fluids, are where this cancer begins.
cancer of the urothelium. The urothelium, the tissue lining your bladder, kidneys, and other urinary system organs, is where this cancer develops.
Sarcoma. Muscle or connective tissue is where this kind of cancer first appears.
Signs
Not every cancer results in visible alterations. However, penile cancer typically results in a change in the appearance of your penis. There may be a lump and discoloration of the skin on your penis.
Symptoms of penile cancer include:
A sore or bump that doesn’t hurt and could leak
Flat growths with a blueish-brown appearance
Something that smells bad beneath your foreskin Rash
Skin thickening or color change
little, crusty lumps
inflammation and swelling, particularly in the penis’ head (balanitis)
These symptoms are sometimes brought on by less serious illnesses including allergies and infections. Don’t leave anything to chance, though. To ensure that early-stage cancer is not left untreated, it is preferable to have a medical professional examine it.
Causes
When healthy cells alter and proliferate uncontrollably, cancer results. However, scientists are unsure of the initial reason of that transformation.
Although they haven’t discovered any reasons, researchers have discovered risk factors.
Treatment
Circumcision. Your doctor might remove the tissue if the cancer is limited to your foreskin.
Cryotherapy. Extreme cold is used in this therapy to kill the tumor.
Excision. Your doctor might remove the tumor or cancerous cells from your penis.
Ablation via laser. In order to eliminate the tumor, this treatment uses lasers that produce extremely high temperatures.
creams with medication. You apply this lotion to your penis on a regular basis. Imiciquimod and fluorouracil are common medications.
Mohs surgery. In order to reach the healthy tissue underlying, your healthcare practitioner will remove the malignant skin layer by layer throughout this treatment.
radiation treatment. Before surgery, your doctor might employ energy beams, such as X-rays, to reduce a tumor or kill cancer cells.
Summary
Receiving a diagnosis of penile cancer is a life-altering event that causes a flurry of feelings and questions. Feeling overburdened is normal and acceptable, so it’s crucial to look after yourself during this time. Consult your physician. In addition to discussing possible treatment choices, they can direct you to resources for both emotional and practical support. Rely on your loved ones and medical team. This is not unique to you.
PELVIC ORGAN PROLAPSE
Pelvic organ prolapse. Prolapse of the pelvic organs such as the uterus, bladder,, rectum, and vagina is known as pelvic organ prolapse. The muscles, ligaments, and tissues that support your pelvic organs known as the pelvic floor become insufficiently strong to keep your organs in place. Like a hammock, the pelvic floor provides support for the organs in your pelvis from below. The organs they support may droop into the vagina or move out of position if these supports get too loose. Your pelvic floor may become weaker as you age or after giving birth.
PELVIC ORGAN PROLAPSE
It is a disorder in which one or more organs (the vagina, uterus, bladder, and rectum) sag due to weak pelvic muscles. In more extreme situations, an organ protrudes outside of your body or onto another organ. Treatments to correct the prolapse and alleviate your symptoms may be suggested by your healthcare practitioner.
Types
prolapse of the anterior vaginal wall (bladder drop). Your bladder may slide out of position and protrude into your vagina if the pelvic floor muscles above it are weak. Cystocele is another name for this kind of prolapse. The most prevalent kind of POP is anterior vaginal wall prolapse.
Urethrocele. If you have weak pelvic floor muscles, your urethra may descend. A fallen bladder is frequently followed by a dropped urethra.
prolapse of the posterior vaginal wall (rectocele). Your rectum may protrude onto the rear wall of your vagina due to weak pelvic floor muscles between it and your vagina.
Signs
Feeling as though something is dropping out of your vagina is the most typical symptom. Other signs and symptoms include:
Pressure or fullness in your vagina
Pelvic fullness, pressure, or soreness
Dyspareunia, or pressure or pain during sexual activity
Changes in the way you urinate or defecate
The location of the prolapse determines your symptoms. Your doctor can identify the areas where your pelvic floor is weaker if you tell them about your problems.
Causes
giving delivery vaginally. The most frequent reason for prolapse is this. Your pelvic floor muscles are more likely to deteriorate if you have twins or triplets, have many vaginal deliveries, have a huge baby (fetal macrosomia), or have a vacuum or forceps delivery.
the process of aging. As you age, your muscles become weaker. Declining estrogen is one of the factors. Your body makes less estrogen while you go through menopause. Your pelvic floor’s supporting connective tissues may deteriorate as a result of the deterioration.
weighing more than average. According to studies, those who are overweight or obese have a higher risk of developing POP than those who are within a healthy weight range.
Treatment
pessary vaginal. To keep a drooping organ in place, your healthcare professional can install this detachable silicone device into your vagina.
Kegel exercises for the pelvic floor. These are pelvic floor strengthening exercises. To evaluate the strength of specific muscles and teach you specific exercises to train them, your healthcare physician could recommend that you see a pelvic floor specialist or urogynecologist.
A shortened vagina is the consequence of the obliterative operation known as colpocleisis. It stops any organs from protruding from your body. If you no longer want penetrative sex and are too weak for reconstructive surgery, this is a good alternative.
Reconstructive surgery restores the organs to their normal position and strengthens the weak areas of your pelvic floor.
Summary
Pelvic organ prolapse is not a life-threatening condition, but it doesn’t mean you have to accept it. You may experience symptoms that make it difficult to fully enjoy life and engage in activities you enjoy. Recognize that you are not alone and that women frequently experience pelvic floor problems. If you believe that your pelvic floor is weak, don’t be afraid to discuss it with your doctor.
Plantar Fascia
Peripheral Neuropathy
Penile Cancer
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